Cell Culture Media, Supplements, and Reagents
Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | MFCD00865788 | 99.9% | C22H33N3O6 | 5 MG
Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat. It reduces plasma ACE activity and can be used in the research of hypertension (including essential and renal hypertension) and congestive heart failure.
- Orally active prodrug of Cilazaprilat
- Reduces plasma ACE activity
- Applicable in research for hypertension (essential and renal) and congestive heart failure
- Evokes a maximum degree of plasma ACE inhibition (-76%) in rats
- Dose-dependently reduces plasma ACE activity and pressor response to angiotensin in cats
- Gradually reduces blood pressure in dogs with volume-depleted renal hypertension
- Decreases blood pressure, reduces heart weight to body weight ratio, and improves postischemic myocardial function in hyperthyroid rats
Medchemexpress LLC HY-A0008 10mg Medchemexpress, Talipexole dihydrochloride CAS:36085-73-1 Purity:>98%
Medchemexpress, HY-A0008 10mg Talipexole dihydrochloride CAS:36085-73-1 Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Pemirolast potassium | 100299-08-9 | 99.99% | 500 MG
Pemirolast potassium is an orally active antiallergic agent that attenuates hypersensitivity reactions. It can be used for bronchial asthma and conjunctivitis research.
- Orally active antiallergic agent
- Attenuates paclitaxel hypersensitivity reactions
- Used for bronchial asthma research
- Used for conjunctivitis research
Sigma Aldrich Fine Chemicals Biosciences Nifurtimox >=98% (HPLC) | 23256-30-6 | MFCD00869254 | 25MG
Nifurtimox >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 287.29 | 23256-30-6 | MFCD00869254 | 25MG
Gold Biotechnology Inc Ciprofloxacin HCl 10 g
Ciprofloxacin is a second generation fluoroquinolone antibiotic targeting a broad-spectrum of bacteria and mycoplasma. It is nalidixic acid analog and has few known resistant strains. Ciprofloxacin is also effective as a plant fungicide. Ciprofloxacin HCl is freely soluble in water. GoldBio also offers Ciprofloxacin, a purer form of the antibiotic which does not contain HCl, but is sparingly soluble in water.
Medchemexpress LLC Asymmetric-dimethylarginine-d6 dihydrochloride | 1313730-20-9 | 99.5% | 281.21 | 1 MG
Asymmetric-dimethylarginine-d6 (dihydrochloride) is the deuterium labeled Asymmetric-dimethylarginine dihydrochloride. This product is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC AT-1002 TFA | 99.7% | 821.91 | 50 MG
AT-1002 TFA is a 6-mer synthetic peptide, serving as a tight junction regulator and absorption enhancer. It belongs to a novel class of compounds that can reversibly increase the paracellular transport of molecules across the epithelial barrier. AT-1002 can also undergo Cys-Cys dimerization. Studies with Caco-2 cells showed that treatment with AT-1002 for up to 3 hours did not affect cell viability at any concentration. However, at concentrations of 2.5 mg/mL and higher, it reduced cell viability after 24 hours, though cells remained viable if washed after a 3-hour exposure, indicating no irreversible damage.
- Tight junction regulator
- Absorption enhancer
- 6-mer synthetic peptide
Crescent Chemical Co Inc CHLORAMPHENICOL
Chloramphenicol research grade, Ph. Eur. Blocks bacterial protein synthesis by inhibiting the peptidyl transferase activity of the 50S ribosomal subunit. Determination in serum by HPLC (1,2), in meat (3). Molecular basis for chloramphenicol resistance (5,6), effec
Medchemexpress LLC BiP inducer X | 101714-41-4 | 99.6% | 209.22 | 50 MG
BiP inducer X | 101714-41-4 | 99.6% | 209.22 | 50 MG
Medchemexpress LLC Spiramycin I | 24916-50-5 | 5 MG
Spiramycin I is a macrolide antibiotic and antiparasitic that functions by binding to the 50S subunit of the ribosome, thereby blocking peptide chain synthesis. It is intended for research use only and not for sale to patients.
- Exhibits inhibitory activity against Gram-positive bacteria.
- Inhibits B. subtilis, M. luteus, S. aureus, S. epidermidis, and S. pneumoniae.
- Shows cytotoxicity in cancer cells HeLa, KB, MCF-7, HepG2, and U87.
Medchemexpress LLC Kasugamycin hydrochloride (Ksg hydrochloride) | 19408-46-9 | 99.9% | 50 MG
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that exhibits anti-infective activity by binding to 30s and 70s ribosomes, without affecting the 50s subunit. Its mechanism involves mimicking mRNA nucleotides, which consequently disrupts tRNA binding and hinders canonical translation initiation. This compound has also been observed to enhance the sensitivity of mycobacteria to Rifampicin in both in vitro settings and mouse infection models.
- Inhibits P-site tRNA binding by destabilizing mRNA.
- Decreases mistranslation rates of asparagine-to-aspartate and glutamine-to-glutamate.
- Reduces mycobacterial rifampicin phenotypic resistance in wild-type and high mistranslating gatA mutant mycobacterial strains.
- Leads to rapid clearance of *M. tuberculosis* in lung burden in Mtb-infected mice.
- Increases Rifampicin susceptibility by 30-fold.
Medchemexpress LLC Kanamycin sulfate | 25389-94-0 | 100.0% | 582.58 | 1 G
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial agent effective against gram-negative and gram-positive bacteria. It inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. It shows good inhibitory activity against both M. tuberculosis (sensitive and drug-resistant) and K. pneumonia, and is used in studies of tuberculosis and pneumonia.
- Orally active antibacterial agent.
- Effective against gram-negative bacteria.
- Effective against gram-positive bacteria.
- Inhibits translocation.
- Causes misencoding by binding to the 70 S ribosomal subunit.
- Good inhibitory activity against M. tuberculosis (sensitive and drug-resistant).
- Good inhibitory activity against K. pneumonia.
- Used in studies of tuberculosis.
- Used in studies of pneumonia.
Medchemexpress LLC Actinonin | 13434-13-4 | 98.4% | 385.50 | 10 MG
Actinonin is a naturally occurring antibacterial agent produced by Actinomyces. It inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase. Actinonin is also a potent reversible peptide deformylase (PDF) inhibitor and inhibits several MMPs and hmeprin α. It induces apoptosis and exhibits antiproliferative and antitumor activities.
- Inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase
- Potent reversible peptide deformylase (PDF) inhibitor
- Inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α
- Induces apoptosis
- Exhibits antiproliferative and antitumor activities
Medchemexpress LLC HY-B0181 100mg Medchemexpress, Altretamine CAS:645-05-6 Purity:>98%
Medchemexpress, HY-B0181 100mg Altretamine CAS:645-05-6 Altretamine is an alkylating antineoplastic agent. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC LEQ506 | 1204975-42-7 | 98.9% | 432.56 | 100 MG
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50 values of 2 nM in human and 4 nM in mouse. It inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) by decreasing Gli mRNA, with an IC50 approximately 6-fold lower than that of Compound 2. At 1%, LEQ506 achieves 80% to 90% inhibition for Gli1 and 60% to 70% for Ptch1.
- Inhibits smoothened (Smo)
- Has IC50 values of 2 nM in human and 4 nM in mouse
- Inhibits Hedgehog (Hh) signaling
- Decreases Gli1 mRNA by 70% to 80%
- Preferentially inhibits Gli1 over Ptch1 mRNA
- Is an efficacious compound